Shields for small molecules

Selective functionalization: Shields for small molecules.

P rotecting groups have a long history in synthetic chemistry 1. A protecting group is covalently attached to one functional group to block its reactivity while a second functional group undergoes a chemical transformation, after which the protecting group is then removed (Fig. 1a). The use of protecting groups requires both protection and deprotection steps, so efficiency considerations dictat...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Kernels for small molecules

2 Graph kernels 2 2.1 Implementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2 The Spectrum Kernel . . . . . . . . . . . . . . . . . . . . . . . . 2 2.3 The Tanimoto Kernel . . . . . . . . . . . . . . . . . . . . . . . . 3 2.4 The MinMax Kernel . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.5 The Marginalized Kernel . . . . . . . . . . . . . . . . . . . . . . . 3 2.6 ...

Applications of Small Molecules in Muscle Tissue Engineering

Introduction: Skeletal muscles account for about 40% of the total body weight. Every year, hundreds of people lose at least part of their muscle tissue due to illness, war, and accidents. This can lead to disruption of activities such as breathing, movement, and social life. To this end, various therapeutic strategies such as medication therapy, cell therapy and tissue transplantation have been...

Structural Comparisons for Small Molecules

This project set out to create a software application which can be used to compare the structures of molecules. The method that was chosen was put forward by Marcus Ludwig et al. [17] and aimed to create a structure which is representative of the common structural features found within the molecules. Alongside the presentation of their paper, the authors created a Java based implementation of t...